Fig. 2.
Nucleotide sequence analysis of the genomic DNA fragment encompassing exon 7 of the GPIIIa gene. Genomic DNA from patient HS or control DNA was amplified using primers complementary to intronic sequences flanking exon 7 of the GPIIIa gene. The amplified 165-bp cDNA fragment was directly submitted to DNA sequence analysis. Nucleotides 1318 to 1323 encoding amino acids 325 to 327 of the normal GPIIIa gene are displayed on the left and the substitution of Ile325Pro326Gly327 by Met in the patient gene is shown on the right.
