Fig. 5.
![Fig. 5. Growth of human MM cells within SCID-hu mice triggers human IL-6 secretion. RPMI-8226 MM cells (1 × 104) were injected directly into the marrow cavity of the left human fetal bone implant in SCID-hu mice, and secretion of human IL-6 in mouse sera at 4, 8, and 12 weeks was determined by ELISA (A). ARH-77, OCI-My5, U-266, and RPMI-8226 MM cells ([▧] 1 × 104 MM cells; and [] 5 × 104 MM cells) were also injected directly into the marrow cavity of the left human fetal bone implant in SCID-hu mice, and the levels of human IL-6 in sera samples taken from these mice 12 weeks later were measured by ELISA (B).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/90/2/10.1182_blood.v90.2.754/4/bl_0023f5a.jpeg?Expires=1735503958&Signature=tPBEAjiFPr9N~Fpv7oabMurecem1mPpa8BbugPBCHanjT32G8Oy5vwBDfmqPxhsIPcauHZHf6qrL2YmOsyWwT304G7dqKQQI-8LaKjRai8mLQ59IEIF0pC4M7uQ0t1FlQ5aCLG1hf7f6V3BY7rgstbIHL-SA-Ui~SJeEDgxVgff36SEOeHJ7xGKayfuq-jO1zm4ECu-x5fSfL5KAdJY7ZujXYX5j5-v4kZVi4C0deYJcYZdotgtTrE3SIUCRr92xIEZB3UxvcH6P2i28Fttdc0E3Aup476PPjBjtoQQsx8Xb0ykMkuboINkyr-SEenmYENuYFiyr~b~~KVcX-4ithA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Growth of human MM cells within SCID-hu mice triggers human IL-6 secretion. RPMI-8226 MM cells (1 × 104) were injected directly into the marrow cavity of the left human fetal bone implant in SCID-hu mice, and secretion of human IL-6 in mouse sera at 4, 8, and 12 weeks was determined by ELISA (A). ARH-77, OCI-My5, U-266, and RPMI-8226 MM cells ([▧] 1 × 104 MM cells; and [] 5 × 104 MM cells) were also injected directly into the marrow cavity of the left human fetal bone implant in SCID-hu mice, and the levels of human IL-6 in sera samples taken from these mice 12 weeks later were measured by ELISA (B).
