Fig. 4.
Survival of lethally irradiated recipients at 33 days after transplantation. Recipient mice were transplanted with 5 × 105 blood-derived MNC from IL-8–mobilized animals (30 μg IP) pretreated with anti–LFA-1 (100 μg IP) (anti–LFA-1 + IL-8) or saline (saline + IL-8) at day -1. To exclude the possibility that anti–LFA-1 antibodies would interfere with homing of HPC, IL-8–mobilized blood was incubated with anti–LFA-1 (IL-8/anti–LFA-1) in one control experiment. Furthermore, recipient mice were pretreated with anti–LFA-1 (IL-8 + anti–LFA-1) as another control. Survival data are expressed as absolute percentages of two experiments with 10 mice transplanted per group in each experiment.
