Nucleotide sequence comparison of the tumor-derived sequences to the closest germline V_H, D-segment and J_H-gene shown from CDR2. The numbering indicated above each case refers to the codons counted from the beginning of V_H. Sequence identity to germline is indicated by dots in each sequence, each mutation by the appropriate nucleotide. The bottom line in each instance indicates whether a mutation is silent (lowercase) or has led to a replacement amino acid (uppercase). N-additions between V_H and D, as well as between D and J_H, are shown in each sequence. Note the stopcodons in position 89 in BA.