A schematic diagram of Jagged-1 and Jagged-1^ext. The top diagram depicts the protein product ofJagged-1 expressed in 3T3 cells and the bottom diagram the truncated product of Jagged-1^ext. Indicated are the signal peptide (SP), the DSL domain, the EGF repeats, the cysteine rich region (Cys), the transmembrane domain (TM), the myc tag epitope recognized by the 9E10 antibody (myc tag), and the poly-histidines (poly-his).