Fig. 2.
NAC increases in a dose- and time-dependent manner membrane TNFα and TNF-R expression on human T cells. (a) Time-dependent increase of membrane TNFα expression on T cells stimulated with PMA plus ionomycin in the absence (dashed line) or presence (solid line) of 20 mmol/L NAC. Results are expressed in MFI values (mean ± SD, n = 6). *Means P < .01. (b) NAC induces a dose-dependent increase of membrane TNFα (○), TNF-RI (▪), and TNF-RII (□) expression on T cells stimulated for 16 hours with PMA plus ionomycin. Results are expressed in percent of increase (mean ± SD, n = 6). (c) Time-dependent increase of membrane TNF-RII expression by T cells stimulated with PMA plus ionomycin in the absence (dashed line) or presence (solid line) of 20 mmol/L NAC. Results are expressed in MFI values (mean ± SD, n = 6). *Means P < .01.