Representative FISH analyses with the 14q11/TCRα/δ YAC and the 14q32/IgH cosmid. (A) Case Deb showing hybridization of a TCRα/δ YAC to the normal chromosome 14, a G group size chromosome (14G), and a D group size chromosome (14D). (B) The same mitosis as (A) rehybridized with a chromosome 14 paint. (C) Case Gam hybridized with the YAC (red) and the IgH Ig10 cosmid (green) showing a normal chromosome 14 and the presence of an inversion (arrow) with a breakpoint within 14q32 proximal to the IgH locus. (D) Case UPN 957 showing the presence of an inv(14). (E) Case UPN 282 showing hybridization of the TCRα/δ YAC to the normal chromosome 14, a der(14) and a der(10). (F ) Interphase nuclei from UPN 282 showing the presence of three hybridization signals in three of the five nuclei.