Fig. 4.
Four different TLS/FUS-ERG junctions are schematically depicted, and their sequences are indicated. (▨) Denote TLS/FUS exon sequence, (▪) represent ERG exon sequence, and an (□) (7′) indicates the sequence resulting from the possible alternative splicing of TLS/FUS intron 6. Numbers above boxes indicate the exon number of each gene. Vertical lines indicate the nucleotide position of the junction between the two genes. The types of these four transcripts are indicated in the left margin. The junction of type D was first reported here. Additional 3 exons of TLS/FUS exon 8 and ERG exons 7 and 8 are included in the junction position of type B to form a new fusion transcript, type D. Types B and D had in-frame junctions, and types A and C had out-of-frame junctions.