Fig. 4.
Fig. 4. Late-gestation embryos. TFPIK1 genotypes are indicated. (A) Pale, stunted TFPIK1(−/−) E14.5 embryo with hemorrhage in the central canal of the spinal cord (arrow) and tail (arrowhead). (B) TFPIK1(−/−) E16.5 embryo with intercranial hemorrhage (arrowhead) and short, kinked tail; note absence of blood in vasculature. (C) E18.5 embryos. Note short tail, paucity of blood in cranial venous sinuses, and sunken cranial fontenelle in the TFPIK1(−/−) embryo. Microscopic sections of this animal showed intercranial hemorrhage and degeneration of brain tissue.

Late-gestation embryos. TFPIK1 genotypes are indicated. (A) Pale, stunted TFPIK1(−/−) E14.5 embryo with hemorrhage in the central canal of the spinal cord (arrow) and tail (arrowhead). (B) TFPIK1(−/−) E16.5 embryo with intercranial hemorrhage (arrowhead) and short, kinked tail; note absence of blood in vasculature. (C) E18.5 embryos. Note short tail, paucity of blood in cranial venous sinuses, and sunken cranial fontenelle in the TFPIK1(−/−) embryo. Microscopic sections of this animal showed intercranial hemorrhage and degeneration of brain tissue.

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