Effect of SANORG 34006 on stasis-induced venous thrombosis in the rabbit. (A) Dose-response relationships: SANORG 34006 (▪), SR 90107/ORG 31540 (•), or standard heparin (▴) were administered SC 2 hours before stasis and administration of tissue factor as described in Materials and Methods. (B) Effect kinetics: SANORG 34006 (▪), SR 90107/ORG 31540 (•), or standard heparin (▴) were administered SC at the dose of 100 nmol/kg. Their antithrombotic activities were determined at indicated time points after administration. Each point represents the mean ± SEM of 10 animals. Statistical analysis was performed using the Mann-Whitney test: *P < .05 versus controls.