Effect of SANORG 34006 on fibrinogen accretion onto a preformed thrombus in the rabbit jugular vein. A thrombus was formed in the jugular vein of rabbits and ¹²⁵I-fibrinogen (20 μCi) was administered IV 15 minutes later. The indicated doses of SANORG 34006 (▪), SR 90107/ORG 31540 (•), standard heparin (▴), or saline were then administered as a 4-hour infusion. Radioactivity of the thrombus was determined at the end of the 4-hour infusion period. Results are expressed as percent inhibition of¹²⁵I-fibrinogen accretion compared with saline-treated control animals. Each point represents the mean ± SEM of 10 animals. Statistical analysis was performed using the Mann-Whitney test: *P < .05 versus controls.