(A) The nucleotide and predicted amino acid sequences of human CDD (GenEMBL Accession no. AJ000474). (B) Multiple alignment of CDD from different species as indicated: BACSU; Bacillus subtilis (P19079), ECOLI; Escherichia coli (P13652), HAEIN; Haemophilus influenzae, (P44325); HUMAN; Homo sapiens (P32320), MYCGE; Mycoplasma genitalium(P47298), MYCPI; Mycoplasma pirum (P47718), MYCPN;Mycoplasma pneumoniae (P75051), BRUMA; Brugia malayi, (U80980). Exposed regions indicate the active site domains and arrows denote the conserved cysteines/histidines involved in the Zn binding. The conserved glutamate referred to in the text is in bold within the first exposed region. Asterisks represent conserved residues found in all members of the protein family.