Sequence and internucleoside linkages for the ODN studied. A dash (-) between bases indicates a PO linkage, and a slash (/) indicates an MP linkage. Fluorescein attachment to the 5′ and 3′ termini, via a 6-amino-1-hexanol linker, is indicated by ∼F and F∼, respectively. CH, cholesterol; DD, dodecanol; PEG2 and PEG5, polyethylene glycol of average molecular weight 2,000 and 5,000, respectively; POE, N-octyl-oligo-oxyethylene; VITE, vitamin E. In the ODN code, 2B and 3B denote sequences targeting the b2a2 and b3a2 junctional sequences, respectively.