Lineage-independent depletion of hematopoietic progenitor cells by NL4-3. Each colony lineage is expressed as a percentage of total colonies recovered (mean ± SEM). The data are aggregated from 9 time points sampled in three experiments, including 13 animals in week 1, 24 animals in week 2, 18 animals in week 3, and 6 animals in week 4 after infection. Compared with uninfected controls, HIV-1–infected grafts showed a mean reduction of 28% in total thymocytes and of 43% in CFU-C over all time points sampled. (□) CFU-GM; (▧) BFU-E; (▪) CFU-GEMM.