Coagulation in normal and hemophilia C blood at 5 pmol/L initiator, with and without replacement. Using 5 pmol/L TF, coagulation was initiated in normal and hemophilia C blood (see the Materials and Methods; Rand et al34), with and without factor XI replacement (1 U/mL blood). Time courses for TAT are provided (A) after immunoassay analysis of quenched samples from the normal blood (•), hemophilia C blood (patient C2, ○), and hemophilia C blood with factor XI replacement (□). Clot times for the experiments and control tubes are as given in Table 1 and are denoted by arrows for blood from normal (arrow a), hemophilia C (arrow c), and hemophilia C donors with factor XI replacement (arrow b, 1 U/mL). In addition to TAT, FPA (B) and platelet osteonectin (C) profiles are provided. (Symbols and clot times as in [A].) Clot times are as in Table 1 and (A), and curves have been drawn through the points by hand.