FFS from 1 year after the start of treatment according to the molecular response status within the 1st year (Responders: PCR-negative; Nonresponders: PCR-positive status). Landmark: 12 months:P < .001. Only 116 patients with two or more PCR determinations during the first year were included; in addition, 4 patients who failed and 8 censored before 1 year were omitted. According to the landmark rules, patients who achieved a late molecular response (ie, after 1 year) were included in the nonresponders group.