Fig. 3.
Fig. 3. Suppression of AdGFP infection by blocking of VnR (αvβ3 integrin). VnR expressed on megakaryocytic precursor cells was blocked with a saturable dose of monoclonal antibody to VnR (L203) before incubation of the cells with AdGFP (500 MOI). As assessed by flow cytometry 36 hours after infection, the number of GFP-expressing megakaryocytic cells (CD41a+) was reduced from 50% in control culture to 18% in culture that was preincubated with VnR antibodies. (□) Preincubation with anti-VnR antibody (0.1 μg/mL). (▧) No anti-VnR antibody.

Suppression of AdGFP infection by blocking of VnR (αvβ3 integrin). VnR expressed on megakaryocytic precursor cells was blocked with a saturable dose of monoclonal antibody to VnR (L203) before incubation of the cells with AdGFP (500 MOI). As assessed by flow cytometry 36 hours after infection, the number of GFP-expressing megakaryocytic cells (CD41a+) was reduced from 50% in control culture to 18% in culture that was preincubated with VnR antibodies. (□) Preincubation with anti-VnR antibody (0.1 μg/mL). (▧) No anti-VnR antibody.

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