American Society of Hematology

Fig. 2.

$Fig. 2. Immunophenotype of interfollicular neoplastic B cells in paraffin sections of follicular lymphoma. (A-F) Serial sections of a follicular lymphoma (case 13) immunostained for CD20 (A), IgD (B), Ig κ light chain (C), Ig λ light chain (D), Ki67 (E), and bcl-2 protein (F). There are numerous CD20+ B cells both in the follicles and the interfollicular zone. IgD+ cells are concentrated in a narrow follicular mantle and scattered in the interfollicular area. There is Ig κ light chain restriction both in the follicular and interfollicular B cells showing the neoplastic nature of both cell populations. Immunostaining for Ki67 antigen shows that follicular neoplastic B cells have a much higher proliferation fraction than the interfollicular component (E) and Bcl-2 immunostaining shows that bcl-2 is expressed by both follicular and interfollicular neoplastic B cells (F). (A-F, immunoperoxidase)$

Immunophenotype of interfollicular neoplastic B cells in paraffin sections of follicular lymphoma. (A-F) Serial sections of a follicular lymphoma (case 13) immunostained for CD20 (A), IgD (B), Ig κ light chain (C), Ig λ light chain (D), Ki67 (E), and bcl-2 protein (F). There are numerous CD20+ B cells both in the follicles and the interfollicular zone. IgD+ cells are concentrated in a narrow follicular mantle and scattered in the interfollicular area. There is Ig κ light chain restriction both in the follicular and interfollicular B cells showing the neoplastic nature of both cell populations. Immunostaining for Ki67 antigen shows that follicular neoplastic B cells have a much higher proliferation fraction than the interfollicular component (E) and Bcl-2 immunostaining shows that bcl-2 is expressed by both follicular and interfollicular neoplastic B cells (F). (A-F, immunoperoxidase)

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