Inhibition of eosinophil recruitment in P-selectin/ICAM-1–deficient double-mutant mice treated with an anti-VCAM antibody. Ragweed-sensitized P-selectin/ICAM-1–deficient mice were pretreated with either a rat IgG1 antimouse VCAM MoAb or a species- and isotype-matched control antibody. Two hours after the antibody was administered intravenously, the mice were challenged by the intraperitoneal injection of allergen and the number of peritoneal eosinophils enumerated 48 hours later.