Fig. 6.
Histopathologic findings in the spleen (A), bone marrow (B), liver (C), colon (D), skin (E), and lung (F) of mice reconstituted with CD4-depleted BMCs [CY/2X/Bone/2BMT(−CD4)]. Histopathologic examination was performed 40 weeks after the treatment. The spleen and bone marrow show normal architecture with normal hematopoiesis, and there is no remarkable lymphocyte infiltration in the liver, colon, skin, or lung, indicating no GVHD.