Half-life of the anti-gp130 MoAbs in SCID mice. One hundred micrograms of a mixture of B-S12 and B-P8 (A) or B1 and I2 (B) anti-gp130 MoAbs (50 μg each) was injected IP in 4 SCID mice. Another 4 mice were injected with physiological saline. At days 1, 4, 8, 12, 16, 20, or 24 after injection, blood was collected and the concentration of circulating murine Ig was determined by ELISA. Results are the mean values ± SD obtained in the 4 mice. The concentration of murine Ig in mice injected with saline was less than 10 μg/mL.