Comparison of the initial phase of the APC-catalyzed inactivation of platelet-derived factor Va and factor VaLeiden bound to thrombin-activated platelets. Data points from Fig 2A (normal platelet-derived factor Va; solid symbols, solid line) and 2B (platelet-derived factor VaLeiden; open symbols, dashed line) were plotted such that the initial 30 minutes of the reaction could be compared. The inset represents the initial (30 minutes) phase of the APC-catalyzed inactivation of platelet-derived factor Va on thrombin-activated platelets from 5 normal donors. The line drawn through the inactivation profiles for both graphs represents the average of the donors at a given time point and does not represent an attempt to fit the data to a first-order rate equation.
