Effects of A3P5P on ADP-induced aggregation of washed human platelets. (A) Platelet aggregation was induced by 10 μmol/L ADP alone (1) or in the presence of 100 μmol/L A3P5P (2). (B) Platelet shape change induced by 0.3 μmol/L ADP in the presence of 5 mmol/L EDTA (1) was inhibited by 100 μmol/L A3P5P (2). (C and D) A3P5P (100 μmol/L) (2) did not inhibit platelet aggregation induced by 0.1 U/mL thrombin (1, C) or 2 μmol/L U46619 (1, D) in the presence of 0.2 U/mL apyrase.