Fibrin cross-linking in plasma clots of family members where the Asn344 deletion was identified. (A) Fibrin clots in the reaction containing CaCl₂ and thrombin (test). (B) Fibrin clots in the reaction containing EDTA and thrombin (control). In each panel: lane 1, maternal sample; lane 2, paternal sample; lane 3, patient's sample; lane 4, brother's sample; and lane 5, a normal control sample. The symbols α, β, γ represent uncross-linked fibrin chains, α_n represents α chain polymers, and γ-γ represents γ chain dimers.