Localization of VIP receptors, SS receptors, and SP receptors in the various compartments of a human appendix. Successive sections were used. (A) Autoradiogram showing total binding of125I-VIP. Predominant VIP receptor-location is in the zone surrounding lymphoid follicles. (B) CD3 immunohistochemical staining. (C) Hematoxylin-eosin stained section. Bar = 1 mm. (D) Blood vessels stained for F-VIII related antigen. (E) Autoradiogram showing total binding of 125I-Tyr3-octreotide. Predominant SS receptor location is in the germinal centers. (F) DRC-1 immunohistochemical staining for reticulum cells. (G) MIB-1 immunohistochemical staining for proliferating cells. (H) Autoradiogram showing total binding of 125I-BH-SP. Predominant SP receptor location is in the blood vessels, but not in lymphoid tissue.
