Histopathological analysis of the CD2-p13 mice. (A) Macroscopic view of a F4 CD2-p13 transgenic mouse showing an enlarged spleen of 1,100 mg. (B) Photomicrography of a typical T-cell prolymphocyte from a F4 CD2-p13 transgenic mouse. The blood smear was stained with May-Grünwaltd-Giemsa. (C through E) Histology of spleen (C) and liver (D and E) after hematoxylin-eosin staining. (C) The spleen has lost its normal architecture and is infiltrated by prolymphocytes beyond its capsule. (D) Low magnification of the liver showing large amounts of prolymphocytes surrounding portal tracts. (E) High magnification of the liver showing numerous prolymphocytes within sinusoids.