Histological appearance of the spleen from theGATA-1.05 heterozygous mutant and wild-type female mice. Histological sections of the spleens from GATA-1.05heterozygous female mice with severe splenomegaly (A and B;GATA-1.05 heterozygous mouse no. 12 in Table 1) or mild splenomegaly (C and D; heterozygous animal no. 3 in Table 1) are shown. Red pulp (R), white pulp (W), and megakaryocytes (Meg) are indicated. The histological sections of wild-type female mouse spleen (E and F; corresponding to wild-type no. 1 in Table 1) are also shown. Tissues were stained with hematoxyline and eosin. Original magnifications × 20 (A, C, and E) or × 80 (B, D, and F).