Overall survival in relation to cyclin E and p27 expression. (A) Cyclin E expression divided in quartiles, first (——, n = 29), second (– – –, n = 20), third (, n = 25), and fourth (· · ·, n = 24), P = .03; (B) p27 expression divided in quartiles, first (——, n = 25), second (· · ·, n = 25), third (– – –, n = 25), and fourth quartile (, n = 25), P < .001; (C) cyclin E expression divided with a cut-off between the first and second quartile, cyclin E ≤2% (——, n = 29), and cyclin E >2% (· · ·, n = 69), P = .03; (D) p27 expression divided with a cut-off between the first and second quartile, p27 ≤15% (· · ·, n = 23) and p27 >15% (——, n = 77), P < .001.