Alignment of the 24 internal repeats in the ABP-276 and ABP-278 backbone. Alignment of amino acid residues 249-2602 of ABP-278 are shown. The 24 amino acid Hinge I sequence of ABP-278 was inserted between repeats 15 and 16; a 34 amino acid Hinge II sequence of both ABP-276 and ABP-278 was inserted between repeats 23 and 24. A consensus sequence for the repeating unit in ABP-278, derived from residues common to at least 10 of the repeats is listed at the bottom, together with a similar consensus sequence from ABP-280¹⁷ and chicken filamin (MCFil).47