Fig. 3.
Fig. 3. Immune responses of 129Ola × C57BL/6J F3 CD38−/− mice (open symbols) and CD38+/+littermate controls (closed symbols) to a limiting dose of the TD antigen TNP5-KLH in alum. In two of the eight TNP5-KLH in alum immunization experiments described in Fig2, the hapten-specific responses to different doses of antigen were compared (1 μg compared with 10 μg). The data shown are representative of these experiments, and illustrate the titers of hapten-specific IgM, IgG1, and IgE serum antibody at various time points after a primary immunization with 1 μg alum-precipitated TNP5-KLH (10 μg, data not shown). Arrow indicates the time of primary immunization.

Immune responses of 129Ola × C57BL/6J F3 CD38−/− mice (open symbols) and CD38+/+littermate controls (closed symbols) to a limiting dose of the TD antigen TNP5-KLH in alum. In two of the eight TNP5-KLH in alum immunization experiments described in Fig2, the hapten-specific responses to different doses of antigen were compared (1 μg compared with 10 μg). The data shown are representative of these experiments, and illustrate the titers of hapten-specific IgM, IgG1, and IgE serum antibody at various time points after a primary immunization with 1 μg alum-precipitated TNP5-KLH (10 μg, data not shown). Arrow indicates the time of primary immunization.

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