Relationship of drug dose and time to the maximum drug-induced apoptosis (T_m). (A) HL-60, (B) CEM, (C) ANLL patient no. 5, (D) ANLL patient no. 14, (E) ALL patient no. 4, and (F) ALL patient no. 8 leukemic cells were tested with varying doses of DNR, IDR, or MTA. For HL-60 and CEM cells, each point represents the mean (±SD) T_m of three independent experiments; for patient's cells, each point shows T_m determined in a single experiment.