Expressed IgM V_H gene distribution in serial blood samples of HIV infected patients. Each graph depicts the percent expression of Ig V_H gene subgroups 1 through 6, over time in: (I) persons infected with HIV infection and CD4⁺T-cell count of more than 500 cells per mm³ blood; (II) patients with AIDS and a CD4⁺ T-cell count of less than 200 cells per mm³ blood; (III) patients with AIDS, as described in Group II that developed lymphoma at a later date; and Controls, healthy HIV-seronegative adults. One symbol is used for the same subject within a given group.