Variation in the proportions of the major Ig V_H gene subgroups in HIV-infected persons and control subjects over time. The graphs depict the data collected on persons in Group I (top left), Group II (top right), Group III (bottom left), or HIV-seronegative controls (bottom right), as indicated at the top of each graph. The standard deviations (SD) about the mean levels of V_H1, V_H3, or V_H4 over time for each subject are indicated by the symbols. The percent SD about the mean Ig V_H gene subgroup levels are indicated on the far right axis. Lines connect the symbols that correspond to the SD of the mean levels for the same person. Each symbol corresponds to the same symbol and subject as in Fig 1.