Fig. 6.
Fig. 6. The MOZ, TIF2, and MOZ-TIF2fusion proteins. The protein domains of MOZ, TIF2, and the MOZ-TIF2 fusion are presented. C4HC3, zinc finger domain associated with chromatin binding; C2HC, zinc finger domain associated with HAT activity; HAT, histone acetyltransferase; NLS, nuclear localization signals; MYST, MOZ, YBF2, SAS2, and Tip60 homology region; inv(8), breakpoint in acute mixed lineage leukemia; Acidic, acidic domain; t(8;16), breakpoint in AML with erythrophagocytosis; P/G, proline/glutamine-rich region; MET, methionine-rich region; bHLH, basic helix-loop-helix region; PAS,Per/ARNT/Sim homology region; Alt.exon, alternatively spliced exon (AA 869 to 938); AD2, activation domain-2; CID, CBPinteraction domain (contains activation domain-1); NID, nuclear hormone receptor interaction domain; Q-rich, glutamine-rich region. The numbers below each schematic correspond to amino acids.

The MOZ, TIF2, and MOZ-TIF2fusion proteins. The protein domains of MOZ, TIF2, and the MOZ-TIF2 fusion are presented. C4HC3, zinc finger domain associated with chromatin binding; C2HC, zinc finger domain associated with HAT activity; HAT, histone acetyltransferase; NLS, nuclear localization signals; MYST, MOZ, YBF2, SAS2, and Tip60 homology region; inv(8), breakpoint in acute mixed lineage leukemia; Acidic, acidic domain; t(8;16), breakpoint in AML with erythrophagocytosis; P/G, proline/glutamine-rich region; MET, methionine-rich region; bHLH, basic helix-loop-helix region; PAS,Per/ARNT/Sim homology region; Alt.exon, alternatively spliced exon (AA 869 to 938); AD2, activation domain-2; CID, CBPinteraction domain (contains activation domain-1); NID, nuclear hormone receptor interaction domain; Q-rich, glutamine-rich region. The numbers below each schematic correspond to amino acids.

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