High levels of serum sCD14 in relation to ongoing clinical events. Levels of sCD14 in serum from symptomatic HIV-1 patients (CDC groups B and C, n = 63) are especially associated with secondary clinical events. The highest sCD14 concentrations were found in serum from patients (n = 11) with MAC infection (P < .001 compared with patients with other clinical events), but patients with events other than MAC infection (n = 21) also had significant higher sCD14 serum levels than did symptomatic patients without ongoing clinical events (n = 31, P < .001). The bars indicate medians and 25 to 75 percentiles.