FISH analysis of metaphases from patient E.C. with 899e2 (chromosome 8 YAC clone) or 280-A9, 20-G12, 2-B10, 52-M15, and 16-L19 (chromosome 13 PAC clones). Chromosome 8 sequences are highlighted with a red painting probe and YAC or PAC signals are in green. Patient E.C. had an extra normal chromosome 8 in some cells.