Fig. 2.
Long-term monitoring of hematocrit and serum Epo concentration in individual mice injected with rAAV-ET. LD, mice injected with 2.5 × 1010 rAAV-ET genomes; HD, mice injected with 5 × 1010 rAAV-ET genomes. Hematocrit was measured weekly by collecting 40 μL of blood via retro-orbital puncture. Doxycycline (200 μg/mL) was present (red lines) or not (blue lines) in the drinking water. Serum Epo concentration values (in Epo mU/mL) are shown within circles on hematocrit curves at the timepoint they were determined. Hematocrit and serum Epo concentration measured before rAAV-ET injection were: 45.2% ± 1.2% and 20.8 ± 5.4 Epo mU/mL, respectively (n = 14). Dotted lines indicate hematocrit values in animals not injected with rAAV-ET (n = 6).
