Fig. 3.
![Fig. 3. (A) RNase protection analysis of TOPO II, β1, and β2 in control (lanes 2, 4, 6, 8, 10, and 12 at 24, 48, 72, 96, and 120 hours and 120R [recovery in medium after treatment for 120 hours], respectively) and RA-treated (lanes 3, 5, 7, 9, 11, and 13 at 24, 48, 72, 96, and 120 hours and 120R [recovery in medium after treatment for 120 hours], respectively) HL-60 cells. M is the molecular weight marker, and lane 1 is tRNA. (B) Phosphorimager analysis of TOPO II isozymes mRNA relative to globin. The signal intensity of the sample from control cells at 24 hours was set at 100%.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/92/8/10.1182_blood.v92.8.2863/5/blod42020003w.jpeg?Expires=1735847194&Signature=jg0leUvoniF2FV4n057CvpbKEAryeRssbiM7GxteGic6HxMkwv6UqiOjwOT8oWVyANycFqGmf3c4bbrIV~hS70TEgmJDuTSm7Fn9CkNwHJsaTeztpzWc~5dXxyql~2boVUpkmJHp7M3s4bx-bklVhyDolokvva9BNfSCat3jpsEShmfZFed6jlasuY8O36jSXUcL3FPgQYb-xOQpsjjJWzekKw8T4jC3YsvyVRjLzLUf-ghkJHk8EyokyOln3ysExPRwPsaVGHLvgnKiItbekHGtnbpiP0VIGGxP1vi8a89tKihA48cqROole8ToflBm4jE1oyWYqsxcS~ip71~hdA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
(A) RNase protection analysis of TOPO II, β1, and β2 in control (lanes 2, 4, 6, 8, 10, and 12 at 24, 48, 72, 96, and 120 hours and 120R [recovery in medium after treatment for 120 hours], respectively) and RA-treated (lanes 3, 5, 7, 9, 11, and 13 at 24, 48, 72, 96, and 120 hours and 120R [recovery in medium after treatment for 120 hours], respectively) HL-60 cells. M is the molecular weight marker, and lane 1 is tRNA. (B) Phosphorimager analysis of TOPO II isozymes mRNA relative to globin. The signal intensity of the sample from control cells at 24 hours was set at 100%.
