The effect of LPS on vWF mRNA in murine tissues. The concentration of vWF mRNA in tissues from control mice (▪) and mice treated with LPS for 3 hours (▨) was determined using the quantitative RT-PCR approach (Materials and Methods). The results are expressed as the mean concentration of vWF mRNA per microgram of total tissue RNA, with standard deviation (for 3 different mice) indicated by the error bars. Tissue abbreviations: Lu, lung; Sp, spleen; Ao, aorta; B, brain; Adi, adipose; Te, testis; H, heart; Th, thymus; Adr, adrenal; Ki, kidney; Mu, skeletal muscle; Gu, gut; Li, liver.