Effect of pamidronate on G-CSF–induced HPC mobilization in mice. Mice were injected G-CSF (□), pamidronate + G-CSF (▪), pamidronate (•), or saline (○). Six mice of each group were killed on each time point and their WBC counts (A), spleen weights (B), and CFC numbers in the blood (C) were measured as described in Materials and Methods. These data represent the mean ± SEM.