Effect of soluble TF fragments on reverse transendothelial migration of MP. A 48-hour reverse transmigration assay was conducted as described in Fig 2. After 2 hours of incubation during which monocytes accumulated beneath endothelial cell cultures, medium containing anti-TF MoAb VIC7 (10 μg/mL), anti-VII MoAb IIH2 (10 μg/mL), soluble TF representing the full extracellular domain (1-219), or partial fragments thereof was added to the cultures (5 μg/mL). Data are derived from three to eight independent experiments. Statistical differences relative to controls with no MoAb are denoted as (*), P < .05.