Fig. 7.
Effect of anti-TF MoAb on adhesion of unstimulated and LPS-stimulated monocytes to endothelium. Unstimulated monocytes or LPS-stimulated monocytes were incubated with resting (black bars) or TNF-activated (stippled bars) HUVEC grown on collagen for 1 hour in medium without MoAb, or medium containing anti-TF MoAb VIC7, anti-factor VII MoAb IVE4 (tested using unstimulated HUVEC only) at 10 μg/mL, or soluble recombinant TF (tested using unstimulated HUVEC only; 20 μg/mL). The extent of binding was compared with the number of monocytes that bound in the absence of added MoAb. The reduced binding of LPS-stimulated monocytes observed in the presence of VIC7 or recombinant TF is statistically different from the controls without MoAb, P < .02 (*).