The anti-GVHD effect of CD2 + 48 MoAb is not dependent on interference with T:B cognate interaction. Nonirradiated B-cell–deficient B6-SCID recipients were administered 10⁶highly purified bm12 CD4⁺ LN cells. Mice receiving CD2 + 48 MoAb were treated as in Fig 1. The survival data are plotted. The days posttransfer are plotted on the x-axis and the proportion of mice surviving on the y-axis. Mice administered CD2 + 48 MoAb had a significantly (P = .00038) higher actuarial survival rate as compared with controls (n = 8 per group).