Pedigree of G family showing the segregation of the mutation. Dashed lines indicate undefined number of generations. Haplotypes are built with L394R mutation and intragenic polymorphisms. Only haplotypes of members of the family available for the study are shown. Affected subjects, carrier subjects, and unaffected subjects are indicated by solid symbols, half-solid symbols, and open symbols, respectively. The member indicated with a hatched symbol died of bleeding.