Identification of two mutations in patient’s vWF gene. Part of the nucleotide sequence gels of amplified vWF exon 20 (A) and exon 28 (B) for both normal control (c) and patient (p) are shown. The asterisks localize the point mutations: (A) the indicated G2635→A transition alters the encoded sequence from Asp 116 to Asn; (B) the indicated C4975→T transition alters the encoded sequence from Arg896 to stop codon.