Fig. 1. Level of matching achieved by conventional typing methods. Patients and potential donors were typed by serological methods for HLA-A and -B and DNA-based methods for HLA-DRB1 and -DQB1. Limiting dilution analysis was performed in the graft-versus-host direction to assess the frequency of host specific CTL precursors. Pairs with a high CTLp frequency (>1:105 PBMC) were judged to be mismatched at the cellular level.
Fig. 1.

Level of matching achieved by conventional typing methods. Patients and potential donors were typed by serological methods for HLA-A and -B and DNA-based methods for HLA-DRB1 and -DQB1. Limiting dilution analysis was performed in the graft-versus-host direction to assess the frequency of host specific CTL precursors. Pairs with a high CTLp frequency (>1:105 PBMC) were judged to be mismatched at the cellular level.

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