Experimental AIHA in FcγRIII wild-type and FcγRIII KO mice treated with CVF and 2.4G2. Mean hematocrits of FcγRIII wild-type (□) and FcγRIII KO (▪) mice at day 4 after injection induced by the MRBC antibody 34-3C. Hatched areas indicate the differences in AIHA induction obtained by treatments with cobra venom factor to deplete complement C3 (CVF) or with the anti-FcγR MoAb 2.4G2 to block specifically the two low-affinity receptors FcγRII and FcγRIII (2.4G2). Results are expressed as the percentage of mean hematocrit ± SEM obtained from 5 to 10 mice in each group.