Comparison of the intended dose levels of cyclophosphamide and etoposide with the actual given levels achieved on average in all cycles. Intended dose refers to the initial dose level in the first cycle for each patient and to the intended course duration of 8 × 21 days. Actual dose intensities refer to the total given dose and to the actual duration of the course of all given cycles (last cycle taken as 21 days). Patients separated according to sex and arranged in order of increasing initial dose level. (▴) Given DI of C; (•) given DI of E; (▴) intended DI of C; (•) intended DI of E.