The proximal IL-4 promoter (not drawn to scale). NFAT binding sites (the P elements) are indicated by open boxes, and the known Stat6 site is indicated by the solid box. Transcription factors implicated in Th2-specific IL-4 gene expression are indicated below their respective binding sites. A binding site for GATA-3 has not yet been reported.13 NFAT activity is higher in effector Th2 cells (“Activated” NFAT10) and is shown for simplicity binding only to the P1 NFAT site.