American Society of Hematology

Fig. 3.

$Fig. 3. Clonal evolution in PBPC collections from a patient with early chronic phase CML (UPN 4). Results are shown for day 1 and day 3 PBPC harvests. HUMARA, BCR/ABL, and β-actin PCRs were performed as described in Materials and Methods. All cell fractions switch from polyclonality on day 1 to monoclonality on day 3. (−), No prior digest with HpaII and Cfo I; (+), prior digest withHpaII and Cfo I.$

Clonal evolution in PBPC collections from a patient with early chronic phase CML (UPN 4). Results are shown for day 1 and day 3 PBPC harvests. HUMARA, BCR/ABL, and β-actin PCRs were performed as described in Materials and Methods. All cell fractions switch from polyclonality on day 1 to monoclonality on day 3. (−), No prior digest with HpaII and Cfo I; (+), prior digest withHpaII and Cfo I.

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